While Ndutu is an excellent game viewing area throughout the year, the best time to visit the Ndutu plains is from the end of December, when the Great Migration herds begin to arrive from the north, until April, when millions of wildebeest, gazelles, and zebras begin their journey northwards again. Due to the seasonal rains, massive herds of wildebeest and zebra can be seen all over these plains at this time of year. 

Thousands of calves are born within Ndutu during the calving season, making Ndutu a home for new creatures on Earth. Giraffe, impala, elephant, dik dik, lion, cheetah, leopard, hyena, bat-eared fox, genet, jackal, wildcat, and many other animals end up living in Ndutu. The plains, marshes, and lakes to woodland attract an abundance of bird species.